@Article{KifferMontCamaPign:2013:SpApCo,
               author = "Kiffer, Carlos R. V. and Monteiro, Antonio Miguel Vieira and 
                         Camargo, Eduardo Celso Gerbi and Pignatari, Antonio C. C.",
          affiliation = "{} and {Instituto Nacional de Pesquisas Espaciais (INPE)} and 
                         {Instituto Nacional de Pesquisas Espaciais (INPE)} and 
                         Laborat{\'o}rio Especial de Microbiologia Clinica, Department 
                         Doen{\c{c}}as Infecciosas e Parasit{\'a}rias, Universidade 
                         Federal de S{\~a}o Paulo, S{\~a}o Paulo, Brazil",
                title = "A proposed model for understanding human-bacterial interactions: 
                         Space-time approach on community <i>Escherichia coli</i> 
                         occurrence and resistance phenomenon",
              journal = "Advances in Bioscience and Biotechnology",
                 year = "2013",
               volume = "4",
               number = "4",
                pages = "505--508",
             keywords = "Escherichia coli, antimicrobial agents, microbiome.",
             abstract = "Due to ecological effect, it is expected that population exposures 
                         to antimicrobial drugs may lead to micro- organisms modifications, 
                         occasionally leading to re- sistance emergence. The present review 
                         was based on previous empirical data and on related literature 
                         search for quantitative empirical models exploring the hu- 
                         man-bacterial interactions. Our previous studies have shown the 
                         emergence of ciprofloxacin resistant (CIP- R) Escherichia coli 
                         significantly related to previous specific levels of ciprofloxacin 
                         consumption and to urban clusters of CIP-R E. coli. The evidence 
                         of sig- nificant spatial clustering of antimicrobial resistance 
                         (ciprofloxacin resistance E. coli) reinforces the ecolo- gical 
                         effect hypothesis as a major drive in resistance emergence. In 
                         other words, human populations sub- mitted to a certain 
                         ciprofloxacin or quinolone usage level may affect neighbours 
                         within certain geogra- phical areas, not necessarily due to 
                         individual antim- icrobial intake, but as a driving pressure over 
                         a mo- dified circulating E. coli population. Apparently quan- 
                         titative spatial-temporal analytical frameworks may be better for 
                         understanding human-bacterial interac- tions based on any of their 
                         epiphenomena (antimicro- bial consumption, antimicrobial 
                         resistance, geno/phe- notypic characteristics).",
                  doi = "10.4236/abb.2013.44066",
                  url = "http://dx.doi.org/10.4236/abb.2013.44066",
                 issn = "2156-8456 and 2156-8502",
                label = "lattes: 0271662670324136 3 KifferMontCamaPign:2013:SpApCo",
             language = "en",
           targetfile = "ABB_2013041113304729.pdf",
        urlaccessdate = "28 abr. 2024"
}